FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term nuclear protein quality control by the ubiquitin-proteasome system ID (Ontology) GO:0071630 (Gene Ontology)
Definition A protein quality control pathway that results in the breakdown of misfolded, damaged or unassembled proteins via a mechanism in which the proteins are ubiquitinated, and then targeted to nuclear proteasomes for degradation.[ PubMed:20080635 PubMed:21211726 ]
Also Known As "nucleus-associated proteasomal ubiquitin-dependent protein breakdown" ; "nucleus-associated proteasomal ubiquitin-dependent protein catabolism" ; "nucleus-associated proteasomal ubiquitin-dependent protein degradation" (for all, see Synonyms field below)
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Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS       1
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 Genes
 nuclear protein quality control by the ubiquitin-proteasome system (all annotations which use CV term, excluding "NOT" statements)       1
     involved_in | nuclear protein quality control by the ubiquitin-proteasome system       1
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ubiquitin-dependent protein catabolic process
 |__proteasome-mediated ubiquitin-dependent protein catabolic process___________
proteasomal protein catabolic process                                           |
 |__proteasome-mediated ubiquitin-dependent protein catabolic process___________|
cellular response to topologically incorrect protein                            |
 |__cellular response to misfolded protein______________________________________|
proteolysis involved in protein catabolic process                               |
 |__protein quality control for misfolded or incompletely synthesized proteins__|
response to misfolded protein                                                   |
 |__cellular response to misfolded protein______________________________________|
                                                                                nuclear protein quality control by the ubiquitin-proteasome system  1 rec.
                                                                                 |__inner nuclear membrane-associated protein degradation pathway
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Is a protein quality control for misfolded or incompletely synthesized proteins
proteasome-mediated ubiquitin-dependent protein catabolic process
Part of cellular response to misfolded protein
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Synonyms
  • "nucleus-associated proteasomal ubiquitin-dependent protein breakdown" EXACT
    "nucleus-associated proteasomal ubiquitin-dependent protein catabolism" EXACT
    "nucleus-associated proteasomal ubiquitin-dependent protein degradation" EXACT
    "ubiquitin-dependent catabolism of misfolded proteins by nucleus-associated proteasome" EXACT
Secondary IDs
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