FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term NLRP3 inflammasome complex ID (Ontology) GO:0072559 (Gene Ontology)
Definition An inflammasome complex that consists of three components, NLRP3 (NALP3), PYCARD and caspase-1. It is activated upon exposure to whole pathogens, as well as a number of structurally diverse pathogen- and danger-associated molecular patterns (PAMPs and DAMPs) and environmental irritants. Whole pathogens demonstrated to activate the NLRP3 inflammasome complex include the fungi Candida albicans and Saccharomyces cerevisiae, bacteria that produce pore-forming toxins, including Listeria monocytogenes and Staphylococcus aureus, and viruses such as Sendai virus, adenovirus, and influenza virus.[ PubMed:20303873 ]
Also Known As "NALP3 inflammasome complex"
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cytosol_____________________
protein-containing complex__|
                            canonical inflammasome complex
                             |__NLRP3 inflammasome complex
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