General Information
Term	adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation	ID (Ontology)	GO:0086030 (Gene Ontology)
Definition	An adrenergic receptor signaling pathway that contributes to a reduction in cardiac muscle contraction. Beta-adrenergic receptor-induced cardiac relaxation is achieved by a GPCR-activated adenylate cyclase generating cAMP; cAMP then activates the cAMP-dependent protein kinase A (PKA), which phosphorylates the sarcoplasmic reticulum (SR) membrane protein PLB. In its non-phosphorylated state, PLB acts as an inhibitor of the ATPase Ca(2+) pump of the cardiac SR (SERCA2a); inhibition of the pump is relieved upon phosphorylation. The pump removes Ca(2+) from the cytoplasm, thereby preventing cytosolic Ca(2+)-dependent activation of contractile proteins, leading to enhanced muscle relaxation.[ PubMed:10571541 ]
Also Known As	"adrenergic receptor signaling pathway involved in cardiac muscle relaxation" ; "Gs-coupled adrenergic receptor signaling pathway involved in cardiac muscle relaxation"
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General Information

Term

adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation

ID (Ontology)

GO:0086030 (Gene Ontology)

Definition

An adrenergic receptor signaling pathway that contributes to a reduction in cardiac muscle contraction. Beta-adrenergic receptor-induced cardiac relaxation is achieved by a GPCR-activated adenylate cyclase generating cAMP; cAMP then activates the cAMP-dependent protein kinase A (PKA), which phosphorylates the sarcoplasmic reticulum (SR) membrane protein PLB. In its non-phosphorylated state, PLB acts as an inhibitor of the ATPase Ca(2+) pump of the cardiac SR (SERCA2a); inhibition of the pump is relieved upon phosphorylation. The pump removes Ca(2+) from the cytoplasm, thereby preventing cytosolic Ca(2+)-dependent activation of contractile proteins, leading to enhanced muscle relaxation.[ PubMed:10571541 ]

Also Known As

"adrenergic receptor signaling pathway involved in cardiac muscle relaxation" ; "Gs-coupled adrenergic receptor signaling pathway involved in cardiac muscle relaxation"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

No relevant statements available

adenylate cyclase-activating adrenergic receptor signaling pathway
 |__adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process__
G protein-coupled receptor signaling pathway involved in heart process                            |
 |__adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process__|
relaxation of muscle                                                                              |
 |__relaxation of cardiac muscle__________________________________________________________________|
                                                                                         adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation

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Is a	adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process
Part of	relaxation of cardiac muscle
Synonyms & Secondary IDs
Synonyms
	"adrenergic receptor signaling pathway involved in cardiac muscle relaxation" EXACT "adrenergic receptor signaling pathway involved in cardiac muscle relaxation via activation of AC" RELATED "adrenergic receptor-induced cardiac relaxation" RELATED[ PubMed:10571541 ] "Gs-coupled adrenergic receptor signaling pathway involved in cardiac muscle relaxation" EXACT
Secondary IDs

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Parents/Children
View Depth

Relationships

Is a

adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process

Part of

relaxation of cardiac muscle

Synonyms & Secondary IDs

Synonyms

"adrenergic receptor signaling pathway involved in cardiac muscle relaxation" EXACT
"adrenergic receptor signaling pathway involved in cardiac muscle relaxation via activation of AC" RELATED
"adrenergic receptor-induced cardiac relaxation" RELATED[ PubMed:10571541 ]
"Gs-coupled adrenergic receptor signaling pathway involved in cardiac muscle relaxation" EXACT

Secondary IDs

External Crossreferences & Linkouts