General Information
Term	G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate	ID (Ontology)	GO:0086033 (Gene Ontology)
Definition	A G protein-coupled acetylcholine receptor signaling pathway that contributes to a decrease in frequency or rate of heart contraction. Binding of acetylcholine to a G protein-coupled (muscarinic) receptor on the surface of the signal-receiving cell results in the alpha subunit of a coupled G-protein binding to GTP. This results in the separation of the beta-gamma complex from the alpha subunit. Both the alpha subunit, and the beta-gamma complex can continue to signal to bring about membrane hyperpolarization and a reduction in heart rate.
Also Known As	"G-protein coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate" ; "M2 receptor signalling pathway involved in negative regulation of heart rate" ; "muscarinic acetylcholine receptor signaling pathway involved in negative regulation of heart rate" (for all, see Synonyms field below)
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Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
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Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
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General Information

Term

G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate

ID (Ontology)

GO:0086033 (Gene Ontology)

Definition

A G protein-coupled acetylcholine receptor signaling pathway that contributes to a decrease in frequency or rate of heart contraction. Binding of acetylcholine to a G protein-coupled (muscarinic) receptor on the surface of the signal-receiving cell results in the alpha subunit of a coupled G-protein binding to GTP. This results in the separation of the beta-gamma complex from the alpha subunit. Both the alpha subunit, and the beta-gamma complex can continue to signal to bring about membrane hyperpolarization and a reduction in heart rate.

Also Known As

"G-protein coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate" ; "M2 receptor signalling pathway involved in negative regulation of heart rate" ; "muscarinic acetylcholine receptor signaling pathway involved in negative regulation of heart rate" (for all, see Synonyms field below)

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

No relevant statements available

regulation of heart rate by chemical signal
 |__negative regulation of heart rate by acetylcholine____________________________________
regulation of systemic arterial blood pressure by acetylcholine                           |
 |__negative regulation of heart rate by acetylcholine____________________________________|
G protein-coupled acetylcholine receptor signaling pathway                                |
 |__G protein-coupled acetylcholine receptor signaling pathway involved in heart process__|
negative regulation of heart rate                                                         |
 |__negative regulation of heart rate by acetylcholine____________________________________|
G protein-coupled receptor signaling pathway involved in heart process                    |
 |__G protein-coupled acetylcholine receptor signaling pathway involved in heart process__|
                                                                                         G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate

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Is a	G protein-coupled acetylcholine receptor signaling pathway involved in heart process
Part of	negative regulation of heart rate by acetylcholine
Synonyms & Secondary IDs
Synonyms
	"G-protein coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate" EXACT "M2 receptor signalling pathway involved in negative regulation of heart rate" EXACT "muscarinic acetylcholine receptor signaling pathway involved in negative regulation of heart rate" EXACT "muscarinic receptor signalling pathway involved in negative regulation of heart rate" EXACT
Secondary IDs

External Crossreferences & Linkouts

Spanning Tree View Settings

Parents/Children
View Depth

Relationships

Is a

G protein-coupled acetylcholine receptor signaling pathway involved in heart process

Part of

negative regulation of heart rate by acetylcholine

Synonyms & Secondary IDs

Synonyms

"G-protein coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate" EXACT
"M2 receptor signalling pathway involved in negative regulation of heart rate" EXACT
"muscarinic acetylcholine receptor signaling pathway involved in negative regulation of heart rate" EXACT
"muscarinic receptor signalling pathway involved in negative regulation of heart rate" EXACT

Secondary IDs

External Crossreferences & Linkouts