FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term phospholipase C-activating angiotensin-activated signaling pathway involved in heart process ID (Ontology) GO:0086099 (Gene Ontology)
Definition An angiotensin-mediated signaling pathway that contributes to a circulatory system process carried out by the heart, where the activated receptor transmits the signal via Gq-mediated activation of phospholipase C (PLC). PLC hydrolyses phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers inositol-1,4,5,-triphosphate (IP3) and diacylglycerol (DAG). DAG activates protein kinase C (PKC), whilst IP3 binds intracellular receptors to induce the release of Ca2+ from intracellular stores.[ PubMed:17376402 ]
Also Known As "angiotensin receptor signaling pathway via activation of phospholipase C involved in heart process" ; "cardiac angiotensin receptor signaling pathway via activation of PLC" ; "Gq-coupled angiotensin receptor signaling pathway involved in heart process" (for all, see Synonyms field below)
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phospholipase C-activating G protein-coupled receptor signaling pathway
 |__phospholipase C-activating angiotensin-activated signaling pathway__
angiotensin-activated signaling pathway                                 |
 |__phospholipase C-activating angiotensin-activated signaling pathway__|
 |__angiotensin-activated signaling pathway involved in heart process___|
G protein-coupled receptor signaling pathway involved in heart process  |
 |__angiotensin-activated signaling pathway involved in heart process___|
                                                                        phospholipase C-activating angiotensin-activated signaling pathway involved in heart process
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Is a phospholipase C-activating angiotensin-activated signaling pathway
angiotensin-activated signaling pathway involved in heart process
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Synonyms
  • "angiotensin receptor signaling pathway via activation of phospholipase C involved in heart process" EXACT
    "cardiac angiotensin receptor signaling pathway via activation of PLC" EXACT
    "Gq-coupled angiotensin receptor signaling pathway involved in heart process" EXACT[ PubMed:17376402 ]
    "phospholipase C-activating angiotensin-mediated signaling pathway involved in heart process" RELATED
    "PLC-activating angiotensin receptor signaling pathway involved in heart process" EXACT
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