FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term negative regulation of canonical Wnt signaling pathway ID (Ontology) GO:0090090 (Gene Ontology)
Definition Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
Also Known As "negative regulation of canonical Wnt receptor signaling pathway" ; "negative regulation of canonical Wnt receptor signalling pathway" ; "negative regulation of canonical Wnt-activated signaling pathway" (for all, see Synonyms field below)
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Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS      47
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Relevant FlyBase reports
 Gene Groups Genes
 negative regulation of canonical Wnt signaling pathway (all annotations which use CV term, excluding "NOT" statements)       4     47
     involved_in | negative regulation of canonical Wnt signaling pathway       --      47
 NOT | involved_in | negative regulation of canonical Wnt signaling pathway       --       1
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negative regulation of signal transduction
 |__negative regulation of Wnt signaling pathway___
regulation of Wnt signaling pathway                |
 |__negative regulation of Wnt signaling pathway___|
 |__regulation of canonical Wnt signaling pathway__|
                                                   negative regulation of canonical Wnt signaling pathway  51 rec.
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Is a negative regulation of Wnt signaling pathway
regulation of canonical Wnt signaling pathway
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Synonyms
  • "negative regulation of canonical Wnt receptor signaling pathway" EXACT
    "negative regulation of canonical Wnt receptor signalling pathway" EXACT
    "negative regulation of canonical Wnt-activated signaling pathway" EXACT
    "negative regulation of catenin import into nucleus" NARROW
    "negative regulation of catenin protein nuclear translocation" NARROW
    "negative regulation of Wnt receptor signaling pathway through beta-catenin" EXACT
Secondary IDs
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Reactome:R-HSA-3772470 "Negative regulation of TCF-dependent signaling by WNT ligand antagonists"
Reactome:R-HSA-4641258 "Degradation of DVL"