FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term negative regulation of excitatory postsynaptic potential ID (Ontology) GO:0090394 (Gene Ontology)
Definition Any process that prevents the establishment or decreases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential.
Also Known As "negative regulation of excitatory post-synaptic membrane potential" ; "reduction of excitatory postsynaptic membrane potential"
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regulation of signal transduction
 |__modulation of excitatory postsynaptic potential__
regulation of nervous system process                 |
 |__modulation of excitatory postsynaptic potential__|
regulation of membrane potential                     |
 |__modulation of excitatory postsynaptic potential__|
regulation of biological process                     |
 |__negative regulation of biological process________|
modulation of chemical synaptic transmission         |
 |__modulation of excitatory postsynaptic potential__|
excitatory postsynaptic potential                    |
 |__modulation of excitatory postsynaptic potential__|
                                                     negative regulation of excitatory postsynaptic potential
                                                      |__negative regulation of mini excitatory postsynaptic potential
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Is a negative regulation of biological process
modulation of excitatory postsynaptic potential
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Synonyms
  • "negative regulation of EPSP" RELATED
    "negative regulation of excitatory post-synaptic membrane potential" EXACT
    "reduction of excitatory postsynaptic membrane potential" EXACT
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