FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term extrinsic apoptotic signaling pathway ID (Ontology) GO:0097191 (Gene Ontology)
Definition The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered.[ PubMed:17340152 ]
Also Known As "extrinsic apoptotic pathway" ; "extrinsic apoptotic signalling pathway"
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Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS       4
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Relevant FlyBase reports
 Genes
 extrinsic apoptotic signaling pathway (all annotations which use CV term, excluding "NOT" statements)       4
     involved_in | extrinsic apoptotic signaling pathway       4
Spanning Tree (Parents/Children)
Only view relationship: 
apoptotic process
 |__apoptotic signaling pathway______________
signal transduction                          |
 |__cell surface receptor signaling pathway__|
 |__apoptotic signaling pathway______________|
                                             extrinsic apoptotic signaling pathway  8 rec.
                                              |__B cell receptor apoptotic signaling pathway
                                              |__death-inducing signaling complex assembly
                                              |   |__regulation of death-inducing signaling complex assembly(+)
                                              |   |__TRAIL death-inducing signaling complex assembly
                                              |__extrinsic apoptotic signaling pathway in absence of ligand 1 rec.
                                              |   |__regulation of extrinsic apoptotic signaling pathway in absence of ligand(+) 1 rec.
                                              |__extrinsic apoptotic signaling pathway via death domain receptors 3 rec.
                                              |   |__regulation of extrinsic apoptotic signaling pathway via death domain receptors(+) 3 rec.
                                              |   |__TRAIL-activated apoptotic signaling pathway(+)
                                              |__fibroblast growth factor receptor apoptotic signaling pathway
                                              |__regulation of extrinsic apoptotic signaling pathway 4 rec.
                                              |   |__negative regulation of extrinsic apoptotic signaling pathway(+) 3 rec.
                                              |   |__positive regulation of extrinsic apoptotic signaling pathway(+)
                                              |   |__regulation of extrinsic apoptotic signaling pathway in absence of ligand(+) 1 rec.
                                              |   |__regulation of extrinsic apoptotic signaling pathway via death domain receptors(+) 3 rec.
                                              |__ripoptosome assembly involved in extrinsic apoptotic signaling pathway
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Is a cell surface receptor signaling pathway
apoptotic signaling pathway
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Synonyms
  • "death receptor-mediated apoptosis" NARROW
    "extrinsic apoptosis" NARROW
    "extrinsic apoptotic pathway" EXACT
    "extrinsic apoptotic signaling pathway in presence of ligand" NARROW
    "extrinsic apoptotic signalling pathway" EXACT
Secondary IDs
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Reactome:R-HSA-5357769 "Caspase activation via extrinsic apoptotic signalling pathway"