FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term intrinsic apoptotic signaling pathway ID (Ontology) GO:0097193 (Gene Ontology)
Definition The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP).[ PubMed:11919192 PubMed:17340152 PubMed:18852119 ]
Also Known As "intrinsic apoptotic pathway" ; "intrinsic apoptotic signalling pathway" ; "mitochondrial-mediated apoptotic pathway"
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS       2
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 Full annotation statements 
Relevant FlyBase reports
 Genes
 intrinsic apoptotic signaling pathway (all annotations which use CV term, excluding "NOT" statements)       2
     involved_in | intrinsic apoptotic signaling pathway       2
Spanning Tree (Parents/Children)
Only view relationship: 
apoptotic process
 |__apoptotic signaling pathway________
signal transduction                    |
 |__intracellular signal transduction__|
 |__apoptotic signaling pathway________|
                                       intrinsic apoptotic signaling pathway  27 rec.
                                        |__intrinsic apoptotic signaling pathway by p53 class mediator 8 rec.
                                        |   |__intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(+) 7 rec.
                                        |   |__intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator(+)
                                        |   |__regulation of intrinsic apoptotic signaling pathway by p53 class mediator(+) 3 rec.
                                        |__intrinsic apoptotic signaling pathway in response to DNA damage 15 rec.
                                        |   |__intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(+) 7 rec.
                                        |   |__regulation of intrinsic apoptotic signaling pathway in response to DNA damage(+) 3 rec.
                                        |__intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 7 rec.
                                        |   |__neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress(+)
                                        |   |__regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(+) 2 rec.
                                        |__intrinsic apoptotic signaling pathway in response to hypoxia
                                        |   |__regulation of hypoxia-induced intrinsic apoptotic signaling pathway(+)
                                        |__intrinsic apoptotic signaling pathway in response to nitrosative stress
                                        |   |__regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway(+)
                                        |__intrinsic apoptotic signaling pathway in response to osmotic stress
                                        |   |__intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator(+)
                                        |   |__regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(+)
                                        |__intrinsic apoptotic signaling pathway in response to oxidative stress 2 rec.
                                        |   |__intrinsic apoptotic signaling pathway in response to hydrogen peroxide(+)
                                        |   |__neuron intrinsic apoptotic signaling pathway in response to oxidative stress(+)
                                        |   |__regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(+) 2 rec.
                                        |__regulation of intrinsic apoptotic signaling pathway 9 rec.
                                            |__negative regulation of intrinsic apoptotic signaling pathway(+) 6 rec.
                                            |__positive regulation of intrinsic apoptotic signaling pathway(+) 3 rec.
                                            |__regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(+) 2 rec.
                                            |__regulation of hypoxia-induced intrinsic apoptotic signaling pathway(+)
                                            |__regulation of intrinsic apoptotic signaling pathway by p53 class mediator(+) 3 rec.
                                            |__regulation of intrinsic apoptotic signaling pathway in response to DNA damage(+) 3 rec.
                                            |__regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(+)
                                            |__regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway(+)
                                            |__regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(+) 2 rec.
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Is a intracellular signal transduction
apoptotic signaling pathway
Part of
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Synonyms
  • "induction of apoptosis by intracellular signals" RELATED
    "intrinsic apoptosis" NARROW
    "intrinsic apoptotic pathway" EXACT
    "intrinsic apoptotic signalling pathway" EXACT
    "mitochondrial-mediated apoptotic pathway" EXACT
Secondary IDs
hide External Crossreferences & Linkouts
Reactome:R-HSA-109606 "Intrinsic Pathway for Apoptosis"