General Information
Term	hypoxia-inducible factor-1alpha signaling pathway	ID (Ontology)	GO:0097411 (Gene Ontology)
Definition	The series of molecular signals mediated by hypoxia-inducible factor (HIF1) in response to lowered oxygen levels (hypoxia). Under hypoxic conditions, the oxygen-sensitive alpha-subunit of hypoxia-inducible factor (HIF)-1 dimerizes with a HIF1-beta subunit (also called ARNT or aryl-hydrocarbon-receptor nuclear translocator), translocates to the nucleus and activates transcription of genes whose products participate in responding to hypoxia.[ PubMed:16887934 PubMed:26579469 ]
Also Known As	"HIF1alpha pathway" ; "hypoxia-inducible factor signaling" ; "hypoxia-inducible factor-1alpha signalling pathway"
Comment
Links to External Ontologies
	QuickGO data AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS
No relevant records available
Records annotated with this exact term (annotations to child terms are NOT included)
No relevant records available
Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
No relevant statements available

General Information

Term

hypoxia-inducible factor-1alpha signaling pathway

ID (Ontology)

GO:0097411 (Gene Ontology)

Definition

The series of molecular signals mediated by hypoxia-inducible factor (HIF1) in response to lowered oxygen levels (hypoxia). Under hypoxic conditions, the oxygen-sensitive alpha-subunit of hypoxia-inducible factor (HIF)-1 dimerizes with a HIF1-beta subunit (also called ARNT or aryl-hydrocarbon-receptor nuclear translocator), translocates to the nucleus and activates transcription of genes whose products participate in responding to hypoxia.[ PubMed:16887934 PubMed:26579469 ]

Also Known As

"HIF1alpha pathway" ; "hypoxia-inducible factor signaling" ; "hypoxia-inducible factor-1alpha signalling pathway"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

No relevant statements available

response to hypoxia
 |__cellular response to hypoxia______________
signal transduction                           |
 |__intracellular signal transduction_________|
cellular response to stress                   |
 |__cellular response to hypoxia______________|
cellular response to decreased oxygen levels  |
 |__cellular response to hypoxia______________|
                                              hypoxia-inducible factor-1alpha signaling pathway
                                               |__regulation of hypoxia-inducible factor-1alpha signaling pathway
                                                   |__negative regulation of hypoxia-inducible factor-1alpha signaling pathway
                                                   |__positive regulation of hypoxia-inducible factor-1alpha signaling pathway

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	intracellular signal transduction
Part of	cellular response to hypoxia
Synonyms & Secondary IDs
Synonyms
	"HIF1alpha pathway" EXACT "hypoxia-inducible factor signaling" EXACT "hypoxia-inducible factor-1alpha signalling pathway" EXACT
Secondary IDs

External Crossreferences & Linkouts

Spanning Tree View Settings

Parents/Children
View Depth

Relationships

Is a

intracellular signal transduction

Part of

cellular response to hypoxia

Synonyms & Secondary IDs

Synonyms

"HIF1alpha pathway" EXACT
"hypoxia-inducible factor signaling" EXACT
"hypoxia-inducible factor-1alpha signalling pathway" EXACT

Secondary IDs

External Crossreferences & Linkouts