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General Information
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| Term |
hypoxia-inducible factor-1alpha signaling pathway |
ID (Ontology) |
GO:0097411 (Gene Ontology) |
| Definition |
The series of molecular signals mediated by hypoxia-inducible factor (HIF1) in response to lowered oxygen levels (hypoxia). Under hypoxic conditions, the oxygen-sensitive alpha-subunit of hypoxia-inducible factor (HIF)-1 dimerizes with a HIF1-beta subunit (also called ARNT or aryl-hydrocarbon-receptor nuclear translocator), translocates to the nucleus and activates transcription of genes whose products participate in responding to hypoxia.[ PubMed:16887934 PubMed:26579469 ] |
| Also Known As |
"HIF1alpha pathway" ; "hypoxia-inducible factor signaling" ; "hypoxia-inducible factor-1alpha signalling pathway" |
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Links to External Ontologies
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QuickGO data AmiGO data
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Annotations
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Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
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No relevant records available
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Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
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No relevant statements available
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Relationships
