FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term ubiquitin-dependent glycoprotein ERAD pathway ID (Ontology) GO:0097466 (Gene Ontology)
Definition An ERAD pathway whereby endoplasmic reticulum (ER)-resident glycoproteins are targeted for degradation. Includes differential processing of the glycoprotein sugar chains, retrotranslocation to the cytosol and degradation by the ubiquitin-proteasome pathway. A glycoprotein is a compound in which a carbohydrate component is covalently bound to a protein component.[ PubMed:16079177 ]
Also Known As "ER-associated glycoprotein degradation" ; "glycoprotein ERAD" ; "gpERAD"
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Annotations
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Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS       2
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Relevant FlyBase reports
 Gene Groups Genes
 ubiquitin-dependent glycoprotein ERAD pathway (all annotations which use CV term, excluding "NOT" statements)       1      2
     involved_in | ubiquitin-dependent glycoprotein ERAD pathway       --       2
Spanning Tree (Parents/Children)
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glycoprotein metabolic process
 |__glycoprotein catabolic process_________
proteasomal protein catabolic process      |
 |__ERAD pathway___________________________|
protein catabolic process                  |
 |__glycoprotein catabolic process_________|
response to endoplasmic reticulum stress   |
 |__ERAD pathway___________________________|
response to chemical                       |
 |__ERAD pathway___________________________|
carbohydrate derivative catabolic process  |
 |__glycoprotein catabolic process_________|
response to oxygen-containing compound     |
 |__response to glycoprotein_______________|
                                           ubiquitin-dependent glycoprotein ERAD pathway  3 rec.
                                            |__mannose trimming involved in glycoprotein ERAD pathway
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Is a glycoprotein catabolic process
ERAD pathway
response to glycoprotein
Part of
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Synonyms
  • "ER-associated glycoprotein degradation" EXACT
    "glycoprotein ERAD" EXACT
    "gpERAD" EXACT[ PubMed:25092655 ]
    "misfolded or incompletely synthesized glycoprotein catabolic process" BROAD
Secondary IDs
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