FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term skeletal muscle fiber differentiation ID (Ontology) GO:0098528 (Gene Ontology)
Definition The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle fiber cell. Skeletal muscle fiber differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual skeletal muscle fibers fuse to form bigger myotubes and start to contract.
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skeletal muscle tissue development
 |__skeletal muscle cell differentiation__
cell differentiation                      |
 |__skeletal muscle cell differentiation__|
striated muscle cell differentiation      |
 |__myotube differentiation_______________|
                                          skeletal muscle fiber differentiation
                                           |__regulation of skeletal muscle fiber differentiation
                                           |   |__negative regulation of skeletal muscle fiber differentiation(+)
                                           |   |__positive regulation of skeletal muscle fiber differentiation(+)
                                           |   |__regulation of tongue muscle cell differentiation(+)
                                           |__tongue muscle cell differentiation
                                               |__regulation of tongue muscle cell differentiation(+)
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Is a myotube differentiation
skeletal muscle cell differentiation
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