FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term HCN channel complex ID (Ontology) GO:0098855 (Gene Ontology)
Definition A cation ion channel with a preference for K+ over Na+ ions, which is activated by membrane hyperpolarization, and consists of a tetramer of HCN family members. Some members of this family (HCN1, HCN2 and HCN4) are also activated when cAMP binds to their cyclic nucleotide binding domain (CNBD). Channel complexes of this family play an important role in the control of pacemaker activity in the heart.[ PubMed:20829353 ]
Also Known As "K/Na hyperpolarization-activated cyclic nucleotide-gated channel complex" ; "potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel complex"
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Data Class Field Records
Genes (FBgn)  GO_CELLULAR_COMPONENT       1
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 Genes
 HCN channel complex (all annotations which use CV term, excluding "NOT" statements)       1
     part_of | HCN channel complex       1
Spanning Tree (Parents/Children)
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potassium channel complex________
plasma membrane protein complex__|
                                 voltage-gated potassium channel complex
                                  |__HCN channel complex  1 rec.
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Is a voltage-gated potassium channel complex
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Synonyms
  • "HCN1 channel complex" NARROW
    "HCN2 channel complex" NARROW
    "HCN3 channel complex" NARROW
    "HCN4 channel complex" NARROW
    "K/Na hyperpolarization-activated channel 3 complex" NARROW
    "K/Na hyperpolarization-activated cyclic nucleotide-gated channel 1 complex" NARROW
    "K/Na hyperpolarization-activated cyclic nucleotide-gated channel 2 complex" NARROW
    "K/Na hyperpolarization-activated cyclic nucleotide-gated channel 4 complex" NARROW
    "K/Na hyperpolarization-activated cyclic nucleotide-gated channel complex" EXACT
    "potassium/sodium hyperpolarization-activated channel 3 complex" NARROW
    "potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 complex" NARROW
    "potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 complex" NARROW
    "potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 tetramer" RELATED
    "potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 complex" NARROW
    "potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 tetramer" RELATED
    "potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel complex" EXACT
Secondary IDs
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