FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term transforming growth factor beta complex ID (Ontology) GO:0099126 (Gene Ontology)
Definition A protein complex acting as ligand of the transforming growth factor beta receptor complex, typically a homodimer of any of the TFGbeta isoforms. The precursor of TGFbeta proteins is cleaved into mature TGFbeta and the latency-associated peptide (LAP), which remains non-covalently linked to mature TGFbeta rendering it inactive. TGFbeta is activated by dimerization and dissociation of the LAP.[ PubMed:22943793 ]
Also Known As "TGF-beta complex" ; "TGF-beta dimer" ; "TGFB complex" (for all, see Synonyms field below)
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  cellular_component
   |__protein-containing complex
       |__transforming growth factor beta complex
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Is a protein-containing complex
Part of extracellular matrix
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Synonyms
  • "TGF-beta complex" EXACT
    "TGF-beta dimer" EXACT
    "TGFB complex" EXACT
    "TGFB dimer" EXACT
    "TGFbeta complex" EXACT
    "TGFbeta dimer" EXACT
Secondary IDs
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