FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term trans-synaptic signaling ID (Ontology) GO:0099537 (Gene Ontology)
Definition Cell-cell signaling in either direction across the synaptic cleft.
Comment
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS       1
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Genes
 trans-synaptic signaling (all annotations which use CV term, excluding "NOT" statements)       1
     involved_in | trans-synaptic signaling       1
Spanning Tree (Parents/Children)
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  cell-cell signaling
   |__synaptic signaling
       |__trans-synaptic signaling  327 rec.
           |__anterograde trans-synaptic signaling 322 rec.
           |   |__anterograde trans-synaptic signaling by nitric oxide
           |   |__anterograde trans-synaptic signaling by trans-synaptic protein complex
           |   |__chemical synaptic transmission(+) 322 rec.
           |__regulation of trans-synaptic signaling 161 rec.
           |   |__modulation of chemical synaptic transmission(+) 161 rec.
           |   |__regulation of retrograde trans-synaptic signaling by endocanabinoid
           |   |__regulation of retrograde trans-synaptic signaling by neuropeptide(+)
           |   |__regulation of retrograde trans-synaptic signaling by trans-synaptic protein complex
           |__retrograde trans-synaptic signaling 6 rec.
           |   |__retrograde trans-synaptic signaling by lipid(+)
           |   |__retrograde trans-synaptic signaling by neuropeptide(+)
           |   |__retrograde trans-synaptic signaling by soluble gas(+)
           |   |__retrograde trans-synaptic signaling by trans-synaptic protein complex(+)
           |__trans-synaptic signaling by BDNF
           |   |__trans-synaptic signaling by BDNF, modulating synaptic transmission(+)
           |__trans-synaptic signaling by lipid
           |   |__retrograde trans-synaptic signaling by lipid(+)
           |   |__trans-synaptic signaling by endocannabinoid(+)
           |   |__trans-synaptic signaling by lipid, modulating synaptic transmission(+)
           |__trans-synaptic signaling by neuropeptide 1 rec.
           |   |__retrograde trans-synaptic signaling by neuropeptide(+)
           |   |__trans-synaptic signaling by neuropeptide, modulating synaptic transmission(+)
           |__trans-synaptic signaling by soluble gas
           |   |__retrograde trans-synaptic signaling by soluble gas(+)
           |   |__trans-synaptic signaling by carbon monoxide(+)
           |   |__trans-synaptic signaling by nitric oxide(+)
           |   |__trans-synaptic signaling by soluble gas, modulating synaptic transmission(+)
           |__trans-synaptic signaling by trans-synaptic complex
           |   |__anterograde trans-synaptic signaling by trans-synaptic protein complex
           |   |__retrograde trans-synaptic signaling by trans-synaptic protein complex(+)
           |   |__trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission
           |__trans-synaptic signaling via exosome 1 rec.
           |__trans-synaptic signaling, modulating synaptic transmission
               |__trans-synaptic signaling by BDNF, modulating synaptic transmission(+)
               |__trans-synaptic signaling by lipid, modulating synaptic transmission(+)
               |__trans-synaptic signaling by neuropeptide, modulating synaptic transmission(+)
               |__trans-synaptic signaling by soluble gas, modulating synaptic transmission(+)
               |__trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission
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