FB2025_05 , released December 11, 2025

General Information
Term	cytoplasm to vacuole targeting by the NVT pathway	ID (Ontology)	GO:0120113 (Gene Ontology)
Definition	A pathway targeting soluble cytosolic proteins to the vacuole lumen. It uses a selective autophagy receptor protein Nbr1, which is an ortholog of mammalian NBR1, and is remotely related to S. cerevisiae Cvt pathway receptor protein Atg19. Similar to the Cvt pathway, the cargos transported by this pathway are hydrolases, which presumably contribute to the hydrolytic activities in the vacuole lumen. Different from the Cvt pathway, this pathway does not require the macroautophagy machinery, but instead relies on the ESCRT machinery for cargo sequestration. This pathway is observed in the fission yeast S. pombe.[ PubMed:26365378 ]
Also Known As	"protein localization by the Nbr1-mediated vacuolar targeting pathway"
Comment
Links to External Ontologies
	QuickGO data AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS
No relevant records available
Records annotated with this exact term (annotations to child terms are NOT included)
No relevant records available
Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
No relevant statements available

General Information

Term

cytoplasm to vacuole targeting by the NVT pathway

ID (Ontology)

GO:0120113 (Gene Ontology)

Definition

A pathway targeting soluble cytosolic proteins to the vacuole lumen. It uses a selective autophagy receptor protein Nbr1, which is an ortholog of mammalian NBR1, and is remotely related to S. cerevisiae Cvt pathway receptor protein Atg19. Similar to the Cvt pathway, the cargos transported by this pathway are hydrolases, which presumably contribute to the hydrolytic activities in the vacuole lumen. Different from the Cvt pathway, this pathway does not require the macroautophagy machinery, but instead relies on the ESCRT machinery for cargo sequestration. This pathway is observed in the fission yeast S. pombe.[ PubMed:26365378 ]

Also Known As

"protein localization by the Nbr1-mediated vacuolar targeting pathway"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

No relevant statements available

protein targeting_________________________________ intracellular protein transport___________________| vacuolar transport________________________________| protein localization to vacuole___________________| establishment of protein localization to vacuole__| protein targeting to vacuole |__cytoplasm to vacuole targeting by the NVT pathway

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	protein targeting to vacuole
Part of
Synonyms & Secondary IDs
Synonyms
	"protein localization by the Nbr1-mediated vacuolar targeting pathway" EXACT
Secondary IDs

External Crossreferences & Linkouts

Spanning Tree View Settings

Parents/Children
View Depth

Relationships

Is a

protein targeting to vacuole

Part of

Synonyms & Secondary IDs

Synonyms

"protein localization by the Nbr1-mediated vacuolar targeting pathway" EXACT

Secondary IDs

External Crossreferences & Linkouts