General Information
Term	stress-induced homeostatically regulated protein degradation pathway	ID (Ontology)	GO:0120174 (Gene Ontology)
Definition	A stress-inducible protein catabolic pathway that promotes protein quality control by accelerating the degradation of misfolded ER membrane and cytosolic proteins, as well as native proteins. The pathway starts with the activation, by stress, of the Nma111p/Ynm3p serine protease, which cleaves the stress-induced hydrophilin Roq1p, resulting in the generation of a Roq1p cleavage product that selectively interacts with Ubr1p, an E3 ubiquitin ligase. Interaction with the Ubr1p type-1 substrate binding site reprograms the substrate specificity of this ubiquitin ligase resulting in the selective proteasome-mediated degradation of misfolded and native proteins. The pathway ends with degradation of the protein by the cytoplasmic proteasome. Currently, NMA111, ROQ1, UBR1, RAD6, and CDC48 are considered to be involved in this quality control pathway.[ PubMed:29861160 ]
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General Information

Term

stress-induced homeostatically regulated protein degradation pathway

ID (Ontology)

GO:0120174 (Gene Ontology)

Definition

A stress-inducible protein catabolic pathway that promotes protein quality control by accelerating the degradation of misfolded ER membrane and cytosolic proteins, as well as native proteins. The pathway starts with the activation, by stress, of the Nma111p/Ynm3p serine protease, which cleaves the stress-induced hydrophilin Roq1p, resulting in the generation of a Roq1p cleavage product that selectively interacts with Ubr1p, an E3 ubiquitin ligase. Interaction with the Ubr1p type-1 substrate binding site reprograms the substrate specificity of this ubiquitin ligase resulting in the selective proteasome-mediated degradation of misfolded and native proteins. The pathway ends with degradation of the protein by the cytoplasmic proteasome. Currently, NMA111, ROQ1, UBR1, RAD6, and CDC48 are considered to be involved in this quality control pathway.[ PubMed:29861160 ]

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

No relevant statements available

ubiquitin-dependent protein catabolic process
 |__proteasome-mediated ubiquitin-dependent protein catabolic process__
response to stress                                                     |
 |__cellular response to stress________________________________________|
proteasomal protein catabolic process                                  |
 |__proteasome-mediated ubiquitin-dependent protein catabolic process__|
response to stimulus                                                   |
 |__response to chemical_______________________________________________|
cellular response to stimulus                                          |
 |__cellular response to stress________________________________________|
                                                                       stress-induced homeostatically regulated protein degradation pathway

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Is a	cellular response to stress response to chemical proteasome-mediated ubiquitin-dependent protein catabolic process
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Synonyms & Secondary IDs
Synonyms
	"SHRED pathway" RELATED
Secondary IDs

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Is a

cellular response to stress
response to chemical
proteasome-mediated ubiquitin-dependent protein catabolic process

Part of

Synonyms & Secondary IDs

Synonyms

"SHRED pathway" RELATED

Secondary IDs

External Crossreferences & Linkouts