FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term 2-oxoglutarate decarboxylation to succinyl-CoA ID (Ontology) GO:0120551 (Gene Ontology)
Definition The chemical reactions and pathways resulting in the formation of succinyl-CoA from 2-oxoglutarate. In most organisms, this pathway is part of the TCA cycle and comprises a series of three reactions carried out by a multisubunit complex called the '2-oxoglutarate dehydrogenase complex', even though 2-oxoglutarate dehydrogenase activity describes only one of those reactions. The combination of the three reactions can be summarized as: 2-oxoglutarate + coenzyme A + NAD+ -> succinyl-CoA + CO2 + NADH.
Also Known As "2-ketoglutarate dehydrogenase system" ; "2-oxoglutarate dehydrogenase system" ; "2alpha-ketoglutarate dehydrogenase system"
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Annotations
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Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS       4
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 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 2-oxoglutarate decarboxylation to succinyl-CoA (all annotations which use CV term, excluding "NOT" statements)       3      4
     involved_in | 2-oxoglutarate decarboxylation to succinyl-CoA       --       4
Spanning Tree (Parents/Children)
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succinyl-CoA metabolic process
 |__succinyl-CoA biosynthetic process__
aerobic respiration                    |
 |__tricarboxylic acid cycle___________|
dicarboxylic acid metabolic process    |
 |__2-oxoglutarate metabolic process___|
primary metabolic process              |
 |__tricarboxylic acid cycle___________|
acyl-CoA biosynthetic process          |
 |__succinyl-CoA biosynthetic process__|
                                       2-oxoglutarate decarboxylation to succinyl-CoA  7 rec.
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Is a 2-oxoglutarate metabolic process
succinyl-CoA biosynthetic process
Part of tricarboxylic acid cycle
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Synonyms
  • "2-ketoglutarate dehydrogenase system" EXACT
    "2-oxoglutarate dehydrogenase system" EXACT
    "2alpha-ketoglutarate dehydrogenase system" EXACT
Secondary IDs
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MetaCyc:PWY-5084