FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA ID (Ontology) GO:0120552 (Gene Ontology)
Definition The chemical reactions and pathways resulting in the formation of a branched-chain acyl-CoA by the oxidative decarboxylation of a branched-chain alpha-keto acid derived from L-leucine, L-isoleucine or L-valine. This pathway comprises a series of three reactions carried out by a multisubunit complex called the 'branched-chain alpha-keto acid dehydrogenase complex', even though branched-chain alpha-keto acid dehydrogenase activity describes only one of those reactions. The combination of the three reactions can be summarized as: 3-methyl-2-oxobutanoate + coenzyme A + NAD+ -> branched-chain acyl-CoA + CO2 + NADH. Specific substrates include 3-methyl-2-oxobutanoate (a transamination product of L-valine), (S)-3-methyl-2-oxopentanoate (a transamination product of L-isoleucine) and 4-methyl-2-oxopentanoate (a transamination product of L-leucine), which generate the products 2-methylpropanoyl-CoA, 2-methylbutanoyl-CoA and 3-methylbutanoyl-CoA, respectively.
Also Known As "branched-chain 2-oxo acid dehydrogenase system" ; "branched-chain alpha-keto acid dehydrogenase system"
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Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS       4
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Relevant FlyBase reports
 Gene Groups Genes
 branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA (all annotations which use CV term, excluding "NOT" statements)       1      4
     involved_in | branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA       --       4
Spanning Tree (Parents/Children)
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acyl-CoA metabolic process
 |__fatty-acyl-CoA metabolic process_____________
amino acid catabolic process                     |
 |__branched-chain amino acid catabolic process__|
branched-chain amino acid metabolic process      |
 |__branched-chain amino acid catabolic process__|
oxoacid metabolic process                        |
 |__carboxylic acid metabolic process____________|
carboxylic acid catabolic process                |
 |__branched-chain amino acid catabolic process__|
fatty acid derivative metabolic process          |
 |__fatty-acyl-CoA metabolic process_____________|
                                                 branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA  5 rec.
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Is a carboxylic acid metabolic process
fatty-acyl-CoA metabolic process
Part of branched-chain amino acid catabolic process
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Synonyms
  • "branched-chain 2-oxo acid dehydrogenase system" EXACT
    "branched-chain alpha-keto acid dehydrogenase system" EXACT
Secondary IDs
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MetaCyc:PWY-5046