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| Term | cardiac endothelial to mesenchymal transition | ID (Ontology) | GO:0140074 (Gene Ontology) |
| Definition | A transition where a cardiac endothelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. Endocardial cells (specialized endothelial cells that line the heart) undergo EndMT, and give rise to mesenchymal cells necessary for proper heart development. EndMT, specifically generates valve progenitor cells that give rise to the mitral and tricuspid valves. EndMT also contributes to endocardial cushion formation, as well as to generation of cardiac fibroblasts and smooth muscle cells, but not cardiac myocytes.[ PubMed:16162442 PubMed:26053665 ] | ||
| Also Known As | "EndMT" ; "EndoMT" | ||
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cell differentiation____ mesenchyme development__| mesenchymal cell differentiation |__cardiac endothelial to mesenchymal transition |__regulation of cardiac endothelial to mesenchymal transition |__negative regulation of cardiac endothelial to mesenchymal transition |__positive regulation of cardiac endothelial to mesenchymal transition |
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| Is a | mesenchymal cell differentiation | ||
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