FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term BCOR complex ID (Ontology) GO:0140261 (Gene Ontology)
Definition A protein-containing complex that monoubiquitinates histone H2A on K119, thus it facilitates the maintenance of the transcriptionally repressive state of some genes, such as BCL6. It consists of the corepressor BCOR or BCORL1, a Polycomb group (PcG) and a SCF ubiquitin ligase subcomplexes. In mammals, the core subunits of the complex include the PcG and PcG-associated proteins NSPC1, RING1, RNF2, and RYBP and the components of the SCF ubiquitin ligase, SKP1, and FBXL10.[ PubMed:16943429 PubMed:22325352 PubMed:24515802 ]
Also Known As "BCL6 corepressor (BCOR) complex" ; "BCOR/BCORL1 complex" ; "non-canonical BCOR-PRC1.1 complex" (for all, see Synonyms field below)
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ubiquitin ligase complex____________
nuclear protein-containing complex__|
                                    nuclear ubiquitin ligase complex
                                     |__BCOR complex
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Is a nuclear ubiquitin ligase complex
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Synonyms
  • "BCL6 corepressor (BCOR) complex" EXACT
    "BCOR/BCORL1 complex" EXACT
    "non-canonical BCOR-PRC1.1 complex" EXACT
    "non-canonical PRC1-BCOR complex" EXACT
    "PRC1.1 complex" EXACT
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