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General Information
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| Term |
insulin-like growth factor binding receptor complex |
ID (Ontology) |
GO:0140308 (Gene Ontology) |
| Definition |
A plasma membrane-localized protein complex that binds insulin-like growth factors (IGF1 or IGF2). This class includes both signaling receptor complexes, such as the insulin-like growth factor 1 receptor (IGF1R) complex, which possesses intrinsic tyrosine kinase activity and initiates intracellular signaling cascades upon ligand binding, and non-signaling receptor complexes such as the insulin-like growth factor 2 receptor (IGF2R), which functions to sequester IGF2 and regulate its bioavailability by directing it to lysosomal degradation. These complexes regulate cell growth, proliferation, survival, and development by modulating IGF signaling.[ PubMed:17475626 PubMed:27140600 PubMed:31594955 PubMed:35749888 ] |
| Also Known As |
"IGF-binding receptor complex" |
| Comment |
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Links to External Ontologies
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QuickGO data AmiGO data
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Annotations
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Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
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No relevant records available
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Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
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No relevant statements available
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Relationships
