General Information
Term	integrated stress response signaling	ID (Ontology)	GO:0140467 (Gene Ontology)
Definition	The series of molecular signals generated in response to diverse stress stimuli required to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eIF2 alpha by one of four members of the eIF2a kinase family (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2), which leads to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, that together promote cellular recovery.[ PubMed:27629041 ]
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General Information

Term

integrated stress response signaling

ID (Ontology)

GO:0140467 (Gene Ontology)

Definition

The series of molecular signals generated in response to diverse stress stimuli required to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eIF2 alpha by one of four members of the eIF2a kinase family (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2), which leads to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, that together promote cellular recovery.[ PubMed:27629041 ]

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

No relevant statements available

response to stress
 |__cellular response to stress_______
intracellular signal transduction     |
 |__intracellular signaling cassette__|
cellular response to stimulus         |
 |__cellular response to stress_______|
                                      integrated stress response signaling  2 rec.
                                       |__GCN2-mediated signaling
                                       |__HRI-mediated signaling
                                       |__PERK-mediated unfolded protein response 2 rec.
                                       |__PKR/eIFalpha signaling

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Is a	cellular response to stress intracellular signaling cassette
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Synonyms
	"ISR" RELATED
Secondary IDs

External Crossreferences & Linkouts
	Wikipedia:Integrated_stress_response

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Is a

cellular response to stress
intracellular signaling cassette

Part of

Synonyms & Secondary IDs

Synonyms

"ISR" RELATED

Secondary IDs

External Crossreferences & Linkouts

Wikipedia:Integrated_stress_response