General Information
Term	MCM complex loading	ID (Ontology)	GO:0140530 (Gene Ontology)
Definition	The protein localization process in which two MCM complexes become associated with chromatin at replication origins. MCM loading begins when origin-bound ORC and Cdc6 (Cdc18 in fission yeast) recruit one MCM2-7/Cdt1 complex to the origin, includes formation of a succession of intermediate complexes and ATP hydrolysis-dependent Mcm2-7 ring closure, and ends when two MCM hexamers fully encircle DNA, and are oriented head-to-head. The double hexamer is inactive for DNA unwinding. MCM loading takes place during G1 phase, and precedes CMG complex assembly.[ PubMed:23603117 PubMed:28191893 PubMed:28191894 PubMed:28501329 ]
Also Known As	"MCM complex loading at replication origin" ; "MCM double hexamer formation at replication origin"
Comment
Links to External Ontologies
	QuickGO data AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS
No relevant records available
Records annotated with this exact term (annotations to child terms are NOT included)
No relevant records available
Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
No relevant statements available

General Information

Term

MCM complex loading

ID (Ontology)

GO:0140530 (Gene Ontology)

Definition

The protein localization process in which two MCM complexes become associated with chromatin at replication origins. MCM loading begins when origin-bound ORC and Cdc6 (Cdc18 in fission yeast) recruit one MCM2-7/Cdt1 complex to the origin, includes formation of a succession of intermediate complexes and ATP hydrolysis-dependent Mcm2-7 ring closure, and ends when two MCM hexamers fully encircle DNA, and are oriented head-to-head. The double hexamer is inactive for DNA unwinding. MCM loading takes place during G1 phase, and precedes CMG complex assembly.[ PubMed:23603117 PubMed:28191893 PubMed:28191894 PubMed:28501329 ]

Also Known As

"MCM complex loading at replication origin" ; "MCM double hexamer formation at replication origin"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

No relevant statements available

cell cycle
 |__cell cycle process_____________________________
cellular process                                   |
 |__cell cycle process_____________________________|
nuclear DNA replication                            |
 |__nuclear cell cycle DNA replication initiation__|
protein-containing complex assembly                |
 |__protein-DNA complex assembly___________________|
protein-DNA complex organization                   |
 |__protein-DNA complex assembly___________________|
cell cycle DNA replication initiation              |
 |__nuclear cell cycle DNA replication initiation__|
                                                   MCM complex loading

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Is a	cell cycle process protein-DNA complex assembly
Part of	nuclear cell cycle DNA replication initiation
Synonyms & Secondary IDs
Synonyms
	"MCM complex loading at replication origin" EXACT "MCM double hexamer formation at replication origin" EXACT
Secondary IDs

External Crossreferences & Linkouts

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Parents/Children
View Depth

Relationships

Is a

cell cycle process
protein-DNA complex assembly

Part of

nuclear cell cycle DNA replication initiation

Synonyms & Secondary IDs

Synonyms

"MCM complex loading at replication origin" EXACT
"MCM double hexamer formation at replication origin" EXACT

Secondary IDs

External Crossreferences & Linkouts