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General Information
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| Term |
MCM complex loading |
ID (Ontology) |
GO:0140530 (Gene Ontology) |
| Definition |
The protein localization process in which two MCM complexes become associated with chromatin at replication origins. MCM loading begins when origin-bound ORC and Cdc6 (Cdc18 in fission yeast) recruit one MCM2-7/Cdt1 complex to the origin, includes formation of a succession of intermediate complexes and ATP hydrolysis-dependent Mcm2-7 ring closure, and ends when two MCM hexamers fully encircle DNA, and are oriented head-to-head. The double hexamer is inactive for DNA unwinding. MCM loading takes place during G1 phase, and precedes CMG complex assembly.[ PubMed:23603117 PubMed:28191893 PubMed:28191894 PubMed:28501329 ] |
| Also Known As |
"MCM complex loading at replication origin" ; "MCM double hexamer formation at replication origin" |
| Comment |
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Links to External Ontologies
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QuickGO data AmiGO data
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Annotations
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Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
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No relevant records available
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Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
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No relevant statements available
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Relationships
