Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
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| Term | EGAD pathway | ID (Ontology) | GO:0140624 (Gene Ontology) |
| Definition | The protein catabolic pathway which selectively extracts ER-resident membrane proteins exported to the Golgi and endosomes for degradation by cytosolic proteasomes. It begins with phosphorylation of the ER-resident membrane protein, which triggers export of the protein from the ER to the Golgi and endosomes, followed by polyubiquitination by the Dsc E3 ubiquitin ligase complex and extraction of the ubiquitinated target, and ends with proteasomal degradation.[ PubMed:31368600 ] | ||
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protein catabolic process__________________________ proteolysis involved in protein catabolic process__| proteasomal protein catabolic process |__EGAD pathway |
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| Is a | proteasomal protein catabolic process | ||
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