FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term target-directed miRNA degradation ID (Ontology) GO:0140958 (Gene Ontology)
Definition The process in which a miRNA is targeted for degradation by a non-coding RNA or mRNA. The binding of an RNA to a target miRNA within a RISC complex results in either ubiquitin-mediated degradation of AGO protein or the displacement of the 3' end of the miRNA, exposing it to nucleases.[ PubMed:33184237 PubMed:36150386 ]
Also Known As "target-directed microRNA degradation" ; "TDMD"
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS       6
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 Full annotation statements 
Relevant FlyBase reports
 Genes
 target-directed miRNA degradation (all annotations which use CV term, excluding "NOT" statements)       6
     acts_upstream_of_positive_effect | target-directed miRNA degradation       1
     involved_in | target-directed miRNA degradation       5
Spanning Tree (Parents/Children)
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RNA catabolic process
 |__miRNA catabolic process_____________________________________________________
miRNA metabolic process                                                         |
 |__miRNA catabolic process_____________________________________________________|
post-transcriptional regulation of gene expression                              |
 |__post-transcriptional gene silencing_________________________________________|
negative regulation of gene expression                                          |
 |__post-transcriptional gene silencing_________________________________________|
regulation of miRNA-mediated gene silencing                                     |
 |__negative regulation of miRNA-mediated gene silencing________________________|
negative regulation of post-transcriptional gene silencing by regulatory ncRNA  |
 |__negative regulation of miRNA-mediated gene silencing________________________|
                                                                                target-directed miRNA degradation  6 rec.
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Is a miRNA catabolic process
post-transcriptional gene silencing
negative regulation of miRNA-mediated gene silencing
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Synonyms
  • "target-directed microRNA degradation" EXACT
    "TDMD" EXACT
Secondary IDs
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