FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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Term transposable element silencing by siRNA-mediated DNA methylation ID (Ontology) GO:0141010 (Gene Ontology)
Definition A transposable element silencing mechanism mediated by RNA-directed DNA methylation. RNA-directed DNA methylation is a gene silencing process in which small interfering RNAs (siRNAs) guide DNA methylation to the siRNA-generating genomic loci and other loci that are homologous to the siRNAs for de novo DNA methylation. This results in a heterochromatin assembly, a chromatin conformation that is refractory to transcription.[ PubMed:28633017 PubMed:32381626 PubMed:32719317 PubMed:36570931 ]
Also Known As "retrostransposon silencing by RdDM" ; "transposable element silencing by siRNA-directed DNA methylation"
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DNA methylation-dependent constitutive heterochromatin formation
 |__gene silencing by siRNA-directed DNA methylation_____________
transposable element silencing                                   |
 |__transposable element silencing by heterochromatin formation__|
constitutive heterochromatin formation                           |
 |__transposable element silencing by heterochromatin formation__|
siRNA-mediated heterochromatin formation                         |
 |__gene silencing by siRNA-directed DNA methylation_____________|
                                                                 transposable element silencing by siRNA-mediated DNA methylation
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Is a gene silencing by siRNA-directed DNA methylation
transposable element silencing by heterochromatin formation
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Synonyms
  • "retrostransposon silencing by RdDM" EXACT
    "retrotransposon silencing by RNA-directed DNA methylation" RELATED
    "retrotransposon silencing by siRNA-directed DNA methylation" NARROW
    "transposable element silencing by siRNA-directed DNA methylation" EXACT
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