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| Term | chromosomal 5-methylcytosine DNA demethylation, oxidation pathway | ID (Ontology) | GO:0141167 (Gene Ontology) |
| Definition | An epigenetic cytosine DNA demethylation pathway that starts with the enzymatic oxidation of the 5-methylcytosine (5meC) to generate 5-hydroxymethylcytosine (5hmC), which successively converted to 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). A DNA glycosylase (e. g. TDG) recognizes the intermediate bases 5fC and 5caC and excises the modified base to initiate its replacement with unmethylated cytosine through base excision repair.[ PubMed:21862972 PubMed:29875631 PubMed:36478523 ] | ||
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DNA metabolic process |__chromosomal 5-methylcytosine DNA demethylation pathway__ positive regulation of gene expression | |__positive regulation of gene expression, epigenetic______| epigenetic regulation of gene expression | |__positive regulation of gene expression, epigenetic______| chromosomal 5-methylcytosine DNA demethylation, oxidation pathway |
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positive regulation of gene expression, epigenetic chromosomal 5-methylcytosine DNA demethylation pathway |
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| Reactome:R-HSA-5221030 "TET1,2,3 and TDG demethylate DNA" | |||
