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General Information
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| Term |
transducin-mediated opsin signaling pathway |
ID (Ontology) |
GO:0141190 (Gene Ontology) |
| Definition |
A G protein-coupled receptor signaling pathway that starts with an opsin molecule being activated by a photon. Opsins include rhodopsin and others visual receptors bind heterotrimeric transducin G proteins upon activation. Activated transducin alpha-subunit activates cGMP phosphodiesterase, which breaks down cGMP. The decrease in cGMP concentration leads to closure of cGMP-gated (CNG) channels, blockage of Na+ influx, and hyperpolarization of photoreceptor plasma membrane, leading to transmission of signal through synapses. The signal is terminated by phosphorylation of the C-terminal tail of rhodopsin by rhodopsin kinase to allow arrestin to bind and block G protein binding. Typical examples are rhabdomeric photoreceptors in the eyes of deuterostomes.[ PubMed:19720651 PubMed:36272560 PubMed:36499010 PubMed:37159291 ] |
| Also Known As |
"cGMP-mediated opsin signaling pathway" ; "ciliary opsin-mediated signaling pathway" ; "cyclic-GMP-mediated opsin signaling pathway" (for all, see Synonyms field below) |
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Links to External Ontologies
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QuickGO data AmiGO data
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Annotations
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Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
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No relevant records available
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Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
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No relevant statements available
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Relationships
