FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term multi-pass translocon complex ID (Ontology) GO:0160064 (Gene Ontology)
Definition A protein complex that mediates the insertion of multi-pass transmembrane proteins into endoplasmic reticulum (ER) membrane. Substrates enter via the lateral gate of the Sec61 translocon. The complex comprises the GEL subcomplex (composed of RAB5IF/OPTI and TMCO1), the BOS subcomplex (composed of NCLN/Nicalin, NOMO and TMEM147) and the PAT subcomplex (composed of WDR83OS/Asterix and CCDC47).[ PubMed:36261522 PubMed:36261528 ]
Also Known As "MPT complex"
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  protein-containing complex
   |__ER membrane insertion complex
       |__multi-pass translocon complex
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Is a ER membrane insertion complex
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Synonyms
  • "MPT complex" EXACT
    "TMCO1 translocon" RELATED
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