General Information
Term	negative regulation of pyruvate decarboxylation to acetyl-CoA	ID (Ontology)	GO:0160218 (Gene Ontology)
Definition	Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate. In most organisms, this pathway links glycolysis to the TCA cycle, by a series of three reactions carried out by a multisubunit complex called the 'pyruvate dehydrogenase complex', even though pyruvate dehydrogenase activity describes only one of those reactions.[ PubMed:26942675 PubMed:36849569 PubMed:37754565 ]
Also Known As	"negative regulation of acetyl-CoA biosynthetic process from pyruvate"
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General Information

Term

negative regulation of pyruvate decarboxylation to acetyl-CoA

ID (Ontology)

GO:0160218 (Gene Ontology)

Definition

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate. In most organisms, this pathway links glycolysis to the TCA cycle, by a series of three reactions carried out by a multisubunit complex called the 'pyruvate dehydrogenase complex', even though pyruvate dehydrogenase activity describes only one of those reactions.[ PubMed:26942675 PubMed:36849569 PubMed:37754565 ]

Also Known As

"negative regulation of acetyl-CoA biosynthetic process from pyruvate"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

No relevant statements available

pyruvate decarboxylation to acetyl-CoA
 |__regulation of pyruvate decarboxylation to acetyl-CoA_____________________
regulation of biosynthetic process                                           |
 |__negative regulation of biosynthetic process______________________________|
negative regulation of metabolic process                                     |
 |__negative regulation of biosynthetic process______________________________|
 |__negative regulation of amide metabolic process___________________________|
 |__negative regulation of nucleobase-containing compound metabolic process__|
 |__negative regulation of small molecule metabolic process__________________|
negative regulation of phosphorus metabolic process                          |
 |__negative regulation of phosphate metabolic process_______________________|
regulation of nucleobase-containing compound metabolic process               |
 |__negative regulation of nucleobase-containing compound metabolic process__|
regulation of amide metabolic process                                        |
 |__negative regulation of amide metabolic process___________________________|
regulation of acyl-CoA biosynthetic process                                  |
 |__regulation of pyruvate decarboxylation to acetyl-CoA_____________________|
regulation of small molecule metabolic process                               |
 |__negative regulation of small molecule metabolic process__________________|
                                                                             negative regulation of pyruvate decarboxylation to acetyl-CoA

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Is a	negative regulation of biosynthetic process regulation of pyruvate decarboxylation to acetyl-CoA negative regulation of amide metabolic process negative regulation of nucleobase-containing compound metabolic process negative regulation of phosphate metabolic process negative regulation of small molecule metabolic process
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Synonyms & Secondary IDs
Synonyms
	"negative regulation of acetyl-CoA biosynthetic process from pyruvate" EXACT
Secondary IDs

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Is a

negative regulation of biosynthetic process
regulation of pyruvate decarboxylation to acetyl-CoA
negative regulation of amide metabolic process
negative regulation of nucleobase-containing compound metabolic process
negative regulation of phosphate metabolic process
negative regulation of small molecule metabolic process

Part of

Synonyms & Secondary IDs

Synonyms

"negative regulation of acetyl-CoA biosynthetic process from pyruvate" EXACT

Secondary IDs

External Crossreferences & Linkouts