FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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Term negative regulation of intracellular signal transduction ID (Ontology) GO:1902532 (Gene Ontology)
Definition Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction.
Also Known As "down regulation of intracellular signal transduction" ; "down regulation of intracellular signaling chain" ; "down-regulation of intracellular signal transduction" (for all, see Synonyms field below)
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regulation of signal transduction
 |__negative regulation of signal transduction_______
 |__regulation of intracellular signal transduction__|
negative regulation of cell communication            |
 |__negative regulation of signal transduction_______|
negative regulation of signaling                     |
 |__negative regulation of signal transduction_______|
negative regulation of response to stimulus          |
 |__negative regulation of signal transduction_______|
                                                     negative regulation of intracellular signal transduction  153 rec.
                                                      |__negative regulation of calcium-mediated signaling
                                                      |   |__negative regulation of calcineurin-mediated signaling(+)
                                                      |   |__negative regulation of CAMKK-AMPK signaling cascade
                                                      |__negative regulation of cAMP/PKA signal transduction 7 rec.
                                                      |__negative regulation of canonical NF-kappaB signal transduction 3 rec.
                                                      |__negative regulation of cell cycle checkpoint 1 rec.
                                                      |   |__negative regulation of DNA damage checkpoint(+) 1 rec.
                                                      |   |__negative regulation of spindle checkpoint(+)
                                                      |__negative regulation of cytoplasmic pattern recognition receptor signaling pathway
                                                      |   |__negative regulation of cGAS/STING signaling pathway
                                                      |   |__negative regulation of inflammasome-mediated signaling pathway
                                                      |   |__negative regulation of MDA-5 signaling pathway
                                                      |   |__negative regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway(+)
                                                      |   |__negative regulation of RIG-I signaling pathway
                                                      |   |__negative regulation of toll-like receptor 3 signaling pathway
                                                      |   |__negative regulation of toll-like receptor 7 signaling pathway
                                                      |   |__negative regulation of toll-like receptor 8 signaling pathway
                                                      |   |__negative regulation of toll-like receptor 9 signaling pathway
                                                      |   |__negative regulation of toll-like receptor 11 signaling pathway
                                                      |   |__negative regulation of toll-like receptor 12 signaling pathway
                                                      |   |__negative regulation of toll-like receptor 13 signaling pathway
                                                      |__negative regulation of endoplasmic reticulum unfolded protein response 2 rec.
                                                      |   |__negative regulation of ATF6-mediated unfolded protein response
                                                      |   |__negative regulation of IRE1-mediated unfolded protein response 1 rec.
                                                      |   |__negative regulation of PERK-mediated unfolded protein response
                                                      |__negative regulation of hippo signaling 51 rec.
                                                      |__negative regulation of hypoxia-inducible factor-1alpha signaling pathway
                                                      |__negative regulation of intracellular steroid hormone receptor signaling pathway 3 rec.
                                                      |   |__negative regulation of androgen receptor signaling pathway
                                                      |   |__negative regulation of ecdysone receptor signaling pathway 3 rec.
                                                      |   |__negative regulation of intracellular estrogen receptor signaling pathway
                                                      |   |__negative regulation of nuclear receptor-mediated glucocorticoid signaling pathway
                                                      |__negative regulation of intrinsic apoptotic signaling pathway 6 rec.
                                                      |   |__negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(+) 1 rec.
                                                      |   |__negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
                                                      |   |__negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator(+) 2 rec.
                                                      |   |__negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(+) 2 rec.
                                                      |   |__negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(+)
                                                      |   |__negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway
                                                      |   |__negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(+) 2 rec.
                                                      |__negative regulation of MAPK cascade 53 rec.
                                                      |   |__negative regulation of ERK1 and ERK2 cascade 23 rec.
                                                      |   |__negative regulation of ERK5 cascade
                                                      |   |__negative regulation of JNK cascade(+) 29 rec.
                                                      |   |__negative regulation of MAP kinase activity(+) 1 rec.
                                                      |   |__negative regulation of p38MAPK cascade
                                                      |   |__negative regulation of pheromone response MAPK cascade
                                                      |   |__negative regulation of stress-activated MAPK cascade(+) 2 rec.
                                                      |__negative regulation of nitric oxide mediated signal transduction
                                                      |   |__negative regulation of nitric oxide-cGMP mediated signal transduction
                                                      |__negative regulation of non-canonical NF-kappaB signal transduction
                                                      |__negative regulation of peroxisome proliferator activated receptor signaling pathway
                                                      |__negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 11 rec.
                                                      |__negative regulation of phospholipase C/protein kinase C signal transduction
                                                      |__negative regulation of phosphorelay signal transduction system
                                                      |   |__negative regulation of ethylene-activated signaling pathway
                                                      |__negative regulation of protein kinase C signaling
                                                      |__negative regulation of retinoic acid receptor signaling pathway
                                                      |__negative regulation of signal transduction by p53 class mediator 2 rec.
                                                      |   |__negative regulation of DNA damage response, signal transduction by p53 class mediator 1 rec.
                                                      |   |__negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator(+) 2 rec.
                                                      |__negative regulation of SMAD protein signal transduction 1 rec.
                                                      |__negative regulation of small GTPase mediated signal transduction 8 rec.
                                                      |   |__negative regulation of ARF protein signal transduction 1 rec.
                                                      |   |__negative regulation of Rac protein signal transduction
                                                      |   |__negative regulation of Ras protein signal transduction 4 rec.
                                                      |   |__negative regulation of Rho protein signal transduction 1 rec.
                                                      |   |__negative regulation of septation initiation signaling
                                                      |__negative regulation of SREBP signaling pathway
                                                      |   |__negative regulation of SREBP signaling pathway in response to increased oxygen levels
                                                      |   |__SREBP-SCAP complex retention in endoplasmic reticulum
                                                      |__negative regulation of stress-activated protein kinase signaling cascade 3 rec.
                                                      |   |__negative regulation of stress-activated MAPK cascade(+) 2 rec.
                                                      |__negative regulation of thyroid hormone receptor signaling pathway
                                                      |__negative regulation of TOR signaling 23 rec.
                                                      |   |__negative regulation of TORC1 signaling 18 rec.
                                                      |   |__negative regulation of TORC2 signaling 1 rec.
                                                      |__negative regulation of vitamin D receptor signaling pathway
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Is a negative regulation of signal transduction
regulation of intracellular signal transduction
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Synonyms
  • "down regulation of intracellular signal transduction" EXACT
    "down regulation of intracellular signal transduction pathway" NARROW
    "down regulation of intracellular signaling cascade" NARROW
    "down regulation of intracellular signaling chain" EXACT
    "down regulation of intracellular signaling pathway" RELATED
    "down regulation of signal transduction via intracellular signaling cascade" RELATED
    "down regulation of signal transmission via intracellular cascade" NARROW
    "down-regulation of intracellular signal transduction" EXACT
    "down-regulation of intracellular signal transduction pathway" NARROW
    "down-regulation of intracellular signaling cascade" RELATED
    "down-regulation of intracellular signaling chain" EXACT
    "down-regulation of intracellular signaling pathway" RELATED
    "down-regulation of signal transduction via intracellular signaling cascade" RELATED
    "down-regulation of signal transmission via intracellular cascade" RELATED
    "downregulation of intracellular signal transduction" EXACT
    "downregulation of intracellular signal transduction pathway" NARROW
    "downregulation of intracellular signaling cascade" NARROW
    "downregulation of intracellular signaling chain" EXACT
    "downregulation of intracellular signaling pathway" RELATED
    "downregulation of signal transduction via intracellular signaling cascade" RELATED
    "downregulation of signal transmission via intracellular cascade" NARROW
    "inhibition of intracellular signal transduction" NARROW
    "inhibition of intracellular signal transduction pathway" NARROW
    "inhibition of intracellular signaling cascade" NARROW
    "inhibition of intracellular signaling chain" NARROW
    "inhibition of intracellular signaling pathway" RELATED
    "inhibition of signal transduction via intracellular signaling cascade" RELATED
    "inhibition of signal transmission via intracellular cascade" NARROW
    "negative regulation of intracellular protein kinase cascade" EXACT
    "negative regulation of intracellular signal transduction pathway" NARROW
    "negative regulation of intracellular signaling cascade" EXACT
    "negative regulation of intracellular signaling chain" EXACT
    "negative regulation of intracellular signaling pathway" RELATED
    "negative regulation of signal transduction via intracellular signaling cascade" RELATED
    "negative regulation of signal transmission via intracellular cascade" NARROW
Secondary IDs
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