FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term maintenance of unfolded protein involved in ERAD pathway ID (Ontology) GO:1904378 (Gene Ontology)
Definition Maintaining an endoplasmic reticulum (ER) protein in an unfolded, soluble state that contributes to its degradation by the cytoplasmic proteasome. Maintaining ER-resident proteins in an unfolded yet soluble state condition after their retro-translocation favors their turnover by the cytosolic proteasome.[ PubMed:21636303 ]
Also Known As "maintenance of unfolded protein involved in endoplasmic reticulum-associated degradation"
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proteasomal protein catabolic process
 |__ERAD pathway__________________________
regulation of protein stability           |
 |__maintenance of unfolded protein_______|
response to endoplasmic reticulum stress  |
 |__ERAD pathway__________________________|
response to chemical                      |
 |__ERAD pathway__________________________|
                                          maintenance of unfolded protein involved in ERAD pathway
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Is a maintenance of unfolded protein
Part of ERAD pathway
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Synonyms
  • "chaperone holdase activity" RELATED[ PubMed:23417671 ]
    "ERAD chaperone-like activity" RELATED
    "holdase activity" RELATED[ PubMed:21636303 ]
    "maintenance of unfolded protein during ERAD" RELATED
    "maintenance of unfolded protein involved in endoplasmic reticulum-associated degradation" EXACT
    "maintenance of unfolded protein involved in endoplasmic reticulum-associated protein degradation pathway" RELATED
    "maintenance of unfolded protein involved in ER-associated degradation pathway" RELATED
Secondary IDs
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