FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term serotonin-activated cation-selective channel complex ID (Ontology) GO:1904602 (Gene Ontology)
Definition A protein complex which is capable of serotonin-activated cation-selective channel activity. Mainly found in pre- and postsynaptic membranes of the brain and gastrointestinal tract. Depending on its location it transports Ca2+, Mg2+, Na+ or K+. It is always a pentamer, containing at least the 5HT3A subunit forming 5HT3A homopentamers or 5HT3A/B heteropentamers. In human, 5HT3A/C, A/D and A/E heteropentamers also exist.[ PubMed:16116092 ]
Also Known As "5-HT-3 receptor complex" ; "5-HT3 receptor complex" ; "5-hydroxytryptamine receptor 3 complex" (for all, see Synonyms field below)
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monoatomic ion channel complex
 |__cation channel complex__________________
receptor complex                            |
 |__serotonin receptor complex______________|
plasma membrane signaling receptor complex  |
 |__neurotransmitter receptor complex_______|
                                            serotonin-activated cation-selective channel complex
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Is a cation channel complex
serotonin receptor complex
neurotransmitter receptor complex
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Synonyms
  • "5-HT-3 receptor complex" EXACT
    "5-HT3 receptor complex" EXACT
    "5-hydroxytryptamine receptor 3 complex" EXACT
    "5HT3 receptor complex" EXACT
    "serotonin receptor complex" BROAD
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