FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term negative regulation of guanyl-nucleotide exchange factor activity ID (Ontology) GO:1905098 (Gene Ontology)
Definition Any process that stops, prevents or reduces the frequency, rate or extent of guanyl-nucleotide exchange factor activity.[ PubMed:20484009 ]
Also Known As "down regulation of GDP-dissociation stimulator activity" ; "down regulation of GDS" ; "down regulation of GEF" (for all, see Synonyms field below)
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positive regulation of molecular function
 |__positive regulation of binding_____________
regulation of binding                          |
 |__positive regulation of binding_____________|
regulation of hydrolase activity               |
 |__regulation of GTPase activity______________|
regulation of molecular function               |
 |__negative regulation of molecular function__|
                                               negative regulation of guanyl-nucleotide exchange factor activity
                                                |__negative regulation of Rho guanyl-nucleotide exchange factor activity
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Is a regulation of GTPase activity
negative regulation of molecular function
positive regulation of binding
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Synonyms
  • "down regulation of GDP-dissociation stimulator activity" EXACT
    "down regulation of GDS" EXACT
    "down regulation of GEF" EXACT
    "down regulation of GNRP" NARROW
    "down regulation of guanyl-nucleotide exchange factor activity" EXACT
    "down regulation of guanyl-nucleotide release factor activity" EXACT
    "down regulation of guanyl-nucleotide releasing factor" EXACT
    "down-regulation of GDP-dissociation stimulator activity" EXACT
    "down-regulation of GDS" EXACT
    "down-regulation of GEF" EXACT
    "down-regulation of GNRP" NARROW
    "down-regulation of guanyl-nucleotide exchange factor activity" EXACT
    "down-regulation of guanyl-nucleotide release factor activity" EXACT
    "down-regulation of guanyl-nucleotide releasing factor" EXACT
    "downregulation of GDP-dissociation stimulator activity" EXACT
    "downregulation of GDS" EXACT
    "downregulation of GEF" EXACT
    "downregulation of GNRP" NARROW
    "downregulation of guanyl-nucleotide exchange factor activity" EXACT
    "downregulation of guanyl-nucleotide release factor activity" EXACT
    "downregulation of guanyl-nucleotide releasing factor" EXACT
    "inhibition of GDP-dissociation stimulator activity" NARROW
    "inhibition of GDS" NARROW
    "inhibition of GEF" NARROW
    "inhibition of GNRP" NARROW
    "inhibition of guanyl-nucleotide exchange factor activity" NARROW
    "inhibition of guanyl-nucleotide release factor activity" NARROW
    "inhibition of guanyl-nucleotide releasing factor" NARROW
    "negative regulation of GDP-dissociation stimulator activity" EXACT
    "negative regulation of GDS" EXACT
    "negative regulation of GEF" EXACT
    "negative regulation of GNRP" NARROW
    "negative regulation of guanyl-nucleotide release factor activity" EXACT
    "negative regulation of guanyl-nucleotide releasing factor" EXACT
Secondary IDs
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