FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term SeqA-DNA complex ID (Ontology) GO:1990097 (Gene Ontology)
Definition A protein-DNA complex that contains an oligomer of SeqA bound to GATC sites in methylated or newly-synthesized, hemi-methylated double-stranded DNA, with preference for the latter. Binding of SeqA to hemimethylated DNA sequesters oriC, prevents re-methylation of DNA by Dam and in turn stops premature re-initiation of replication during one replication cycle.[ PubMed:12379844 PubMed:15933720 PubMed:23149570 ]
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  protein-containing complex
   |__protein-DNA complex
       |__SeqA-DNA complex
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Synonyms
  • "SeqA-dsDNA complex" NARROW
    "SeqA-hemimethylated DNA complex" NARROW
    "SeqA-hemimethylation dsDNA complex" NARROW
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