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| Term | Bre1-Rad6 ubiquitin ligase complex | ID (Ontology) | GO:1990302 (Gene Ontology) |
| Definition | A ubiquitin ligase complex consisting of Bre1 and Rad6 that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. It thereby plays a central role in histone code and gene regulation. It also modulates the formation of double-strand breaks during meiosis.[ PubMed:19531475 ] | ||
| Also Known As | "Bre1-Rad6 complex" | ||
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cellular anatomical structure |__intracellular anatomical structure__ catalytic complex | |__transferase complex_________________| Bre1-Rad6 ubiquitin ligase complex |
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| Is a | transferase complex | ||
| Part of | intracellular anatomical structure | ||
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