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| Term | RSP5-BUL ubiquitin ligase complex | ID (Ontology) | GO:1990306 (Gene Ontology) |
| Definition | A ubiquitin ligase complex consisting of RSP5 and BUL components. It polyubiquinates plasma membrane transporters and permeases, required for their endocytosis and subsequent degradation in the vacuole. BUL1 or BUL2, respectively, bind to the target protein, enabling ubiquitylation by Rsp5. Phosphorylation of BUL proteins results in binding to 14-3-3 proteins, protecting the permeases from down-regulation.[ PubMed:9931424 ] | ||
| Also Known As | "RSP5-BUL1 complex" | ||
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protein-containing complex |__intracellular protein-containing complex__ catalytic complex | |__transferase complex_______________________| RSP5-BUL ubiquitin ligase complex |
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intracellular protein-containing complex transferase complex |
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