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| Term | Ire1 complex | ID (Ontology) | GO:1990332 (Gene Ontology) |
| Definition | A type-I transmembrane protein complex located in the endoplasmic reticulum (ER) consisting of an IRE1-IRE1 dimer, which forms in response to the accumulation of unfolded protein in the ER. The dimeric complex has endoribonuclease (RNase) activity and evokes the unfolded protein response (UPR) by cleaving an intron of a mRNA coding for the transcription factor HAC1 in yeast or XBP1 in mammals; the complex cleaves a single phosphodiester bond in each of two RNA hairpins (with non-specific base paired stems and loops of consensus sequence CNCNNGN, where N is any base) to remove an intervening intron from the target transcript.[ PubMed:18191223 PubMed:25437541 ] | ||
| Also Known As | "ER-bound kinase/endoribonuclease (RNase), inositol-requiring enzyme-1" ; "Ire1 complex dimer" ; "Ire1 complex homodimer" (for all, see Synonyms field below) | ||
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endoplasmic reticulum |__endoplasmic reticulum protein-containing complex___________ membrane | |__membrane protein complex___________________________________| organelle membrane | |__endoplasmic reticulum membrane_____________________________| protein-containing complex | |__membrane protein complex___________________________________| |__endoplasmic reticulum protein-containing complex___________| nuclear outer membrane-endoplasmic reticulum membrane network | |__endoplasmic reticulum membrane_____________________________| endoplasmic reticulum subcompartment | |__endoplasmic reticulum membrane_____________________________| protein kinase complex | |__serine/threonine protein kinase complex____________________| endonuclease complex | |__endoribonuclease complex___________________________________| Ire1 complex |
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| Is a |
membrane protein complex endoplasmic reticulum protein-containing complex serine/threonine protein kinase complex endoribonuclease complex |
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| Part of | endoplasmic reticulum membrane | ||
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