FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term CLOCK-BMAL transcription complex ID (Ontology) GO:1990513 (Gene Ontology)
Definition Transcription factor complex which interacts with E-box regulatory elements in target genes, including Period (Per1, Per2, Per3) and Cryptochrome (Cry1, Cry2), to activate their transcription during the daytime. The CRY-PER complexes inhibit CLOCK-BMAL1-driven transcription in a negative feedback loop to generate circadian rhythms.[ PubMed:23229515 ]
Also Known As "CLOCK/BMAL complex"
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Data Class Field Records
Genes (FBgn)  GO_CELLULAR_COMPONENT       1
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 Genes
 CLOCK-BMAL transcription complex (all annotations which use CV term, excluding "NOT" statements)       1
     part_of | CLOCK-BMAL transcription complex       1
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transcription regulator complex_____
nuclear protein-containing complex__|
                                    RNA polymerase II transcription regulator complex
                                     |__CLOCK-BMAL transcription complex  1 rec.
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Is a RNA polymerase II transcription regulator complex
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