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| Term | ANPR-A receptor complex | ID (Ontology) | GO:1990620 (Gene Ontology) |
| Definition | A receptor complex composed of two ANPR-A molecules and expressed in the heart atrium in mammals; it plays a major role in the regulation of blood pressure and salt-fluid volume homeostasis. Binding of the ligand AMP in response to atrial distension (high blood volume) leads to guanylate cyclase activity of the ANPR-A receptor complex, thereby elevating intracellular cGMP levels. The end result is a reduction in blood volume and, therefore, a reduction in cardiac output and systemic blood pressure.[ PubMed:15117952 ] | ||
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protein-containing complex |__receptor complex |__ANPR-A receptor complex |
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| Is a | receptor complex | ||
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