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| Term | calprotectin complex | ID (Ontology) | GO:1990660 (Gene Ontology) |
| Definition | A protein complex composed of S100A8 and S100A9 and capable of limiting Mn(2+) and Zn(2+) availability at sites of infection. Also binds Ca(2+). Expressed and released by neutrophils and epithelial cells, it exhibits broad-spectrum antimicrobial activity attributed to its metal-binding properties. Endogenous ligand of toll-like receptor 4 (TLR4) and of the receptor for advanced glycation end products (RAGE) initiating signal transduction through NF-kappa-B pathways.[ PubMed:25417112 ] | ||
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cellular_component |__protein-containing complex |__calprotectin complex |
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| Is a | protein-containing complex | ||
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