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| Term | mitotic spindle assembly checkpoint MAD1-MAD2 complex | ID (Ontology) | GO:1990728 (Gene Ontology) |
| Definition | A protein complex involved in the assembly of the mitotic checkpoint complex that in turn inhibits the anaphase promoting complex/cyclosome (APC/C). The MAD1 dimer recruits the open form of MAD2 (O-MAD2) turning it into the closed form (C-MAD2) upon binding. C-MAD2 inhibits CDC20, a member of the APC/C, upon release from the MAD1-MAD2 complex.[ PubMed:12006501 PubMed:22898774 ] | ||
| Also Known As | "MAD1-MAD2 complex" | ||
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cellular_component |__protein-containing complex |__mitotic spindle assembly checkpoint MAD1-MAD2 complex |
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| Is a | protein-containing complex | ||
| Part of | cytoplasm | ||
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