FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term GLI-SUFU complex ID (Ontology) GO:1990788 (Gene Ontology)
Definition A protein repressing GLI's transcription factor activity when SMO signaling is inactive. Upon ligand binding to the upstream receptor PTC (Patched) GLI dissociates from SUFU and activates transcription of hedgehog-target genes. In mammals it consists of SUFU and one of the GLI family proteins.[ PubMed:24311597 ]
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cellular_component
 |__protein-containing complex__
cytoplasm                       |
 |__cytosol_____________________|
cellular anatomical structure   |
 |__cytosol_____________________|
                                GLI-SUFU complex
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Is a protein-containing complex
Part of cytosol
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