FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term NPHP complex ID (Ontology) GO:1990957 (Gene Ontology)
Definition A protein complex that is located at the ciliary transition zone and consists of the NPHP4 and NPHP1 proteins. It acts as an organiser of the transition zone inner structure, specifically the Y-shaped links, in conjunction with the MKS complex. It is involved in ciliary protein trafficking and is required for correct functioning of the WNT and Hippo signaling pathways.[ PubMed:18337471 PubMed:21422230 PubMed:21498478 PubMed:21555462 PubMed:25150219 ]
Also Known As "NPHP module"
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cellular_component
 |__protein-containing complex__
cilium                          |
 |__ciliary transition zone_____|
cellular anatomical structure   |
 |__ciliary transition zone_____|
                                NPHP complex
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Is a protein-containing complex
Part of ciliary transition zone
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Synonyms
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