FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term major depressive disorder ID (Ontology) DOID:1470 (Human Disease)
Definition A depressive disorder that is characterized by at least two weeks of loss of interest or pleasure in normally enjoyable activities or depressed mood along with additional cognitive or somatic impairments such as appetite or weight changes, sleep difficulties, psychomotor agitation or retardation, fatigue or loss of energy, diminished ability to think or concentrate, feelings of worthlessness or excessive guilt, and suicidality.
Also Known As "clinical depression" ; "major depression" ; "recurrent major depression" (for all, see Synonyms field below)
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DO.org
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Data Class Field Records
Alleles (FBal)  HUMAN_DISEASE_INTERACTIONS       1
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 Alleles Genes
 major depressive disorder       1      1
 for disease ribbon | Pfeiffer syndrome       --       2
 for disease ribbon | propionic acidemia       --       1
 model of | branchiootorenal syndrome       3       --
 model of | major depressive disorder       1       --
 model of | Pfeiffer syndrome       --       2
 model of | propionic acidemia       --       1
Spanning Tree (Parents/Children)
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  mood disorder
   |__depressive disorder
       |__major depressive disorder  6 rec.
           |__melancholic depression 4 rec.
               |__postpartum depression
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Is a depressive disorder
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Synonyms
  • "clinical depression" EXACT
    "major depression" EXACT
    "recurrent major depression" EXACT
    "single major depressive episode" EXACT
    "unipolar depression" EXACT
Secondary IDs
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EFO:0003761
ICD10CM:F32
ICD10CM:F33.9
ICD9CM:296.2
ICD9CM:296.3
MIM:608520
MIM:608691
NCI:C34796
SNOMEDCT_US_2023_03_01:268621008
SNOMEDCT_US_2023_03_01:36923009
UMLS_CUI:C0024517
UMLS_CUI:C0154409