FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term smoothened signaling pathway ID (Ontology) GO:0007224 (Gene Ontology)
Definition The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.[ PubMed:15057936 PubMed:15205520 ]
Also Known As "hedgehog signaling pathway" ; "smoothened signalling pathway"
Comment
Links to External Ontologies
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS       8
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 smoothened signaling pathway (all annotations which use CV term, excluding "NOT" statements)       2      8
     involved_in | smoothened signaling pathway       --       8
 NOT | involved_in | smoothened signaling pathway       --       2
Spanning Tree (Parents/Children)
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  signal transduction
   |__cell surface receptor signaling pathway
       |__smoothened signaling pathway  104 rec.
           |__mesenchymal smoothened signaling pathway involved in prostate gland development
           |__smoothened signaling pathway involved in dorsal/ventral neural tube patterning
           |__smoothened signaling pathway involved in lung development
           |__smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
           |__smoothened signaling pathway involved in regulation of secondary heart field cardioblast proliferation
           |__smoothened signaling pathway involved in ventral spinal cord patterning
               |__smoothened signaling pathway involved in spinal cord motor neuron cell fate specification
               |__smoothened signaling pathway involved in ventral spinal cord interneuron specification
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Is a cell surface receptor signaling pathway
Part of
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Synonyms
  • "hedgehog signaling pathway" EXACT
    "hh signaling pathway" NARROW
    "hh signalling pathway" NARROW
    "Shh signaling pathway" RELATED
    "smoothened signalling pathway" EXACT
    "Sonic hedgehog signaling pathway" NARROW
Secondary IDs
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Wikipedia:Hedgehog_signaling_pathway