FB2025_05 , released December 11, 2025

General Information
Term	phosphoenolpyruvate-dependent sugar phosphotransferase system	ID (Ontology)	GO:0009401 (Gene Ontology)
Definition	The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC.[ PubMed:31209249 PubMed:33820910 ]
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General Information

Term

phosphoenolpyruvate-dependent sugar phosphotransferase system

ID (Ontology)

GO:0009401 (Gene Ontology)

Definition

The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC.[ PubMed:31209249 PubMed:33820910 ]

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

No relevant statements available

carbohydrate transmembrane transport__ import across plasma membrane_________| carbohydrate import across plasma membrane |__phosphoenolpyruvate-dependent sugar phosphotransferase system |__phosphoenolpyruvate-dependent mannosylglycerate phosphotransferase system

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Is a	carbohydrate import across plasma membrane
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Synonyms & Secondary IDs
Synonyms
	"PTS system" NARROW
Secondary IDs

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Is a

carbohydrate import across plasma membrane

Part of

Synonyms & Secondary IDs

Synonyms

"PTS system" NARROW

Secondary IDs

External Crossreferences & Linkouts